Although technically not part of the Garden Route (it officially ends in Mossel Bay), Hermanus has some of the best views around and offers access to epic ocean activities like windsurfing and shark cage diving.
Hermanus is also an excellent place to watch whales as they migrate down the coast from July through November. Sadly, we found out when we arrived that we missed the whales by a week or so. However, we still loved strolling up and down the cliff path, taking in the beautiful view.
Oh, and you guys didn't think we would just not celebrate Thanksgiving, did you? We waited a day to take advantage of the private kitchen in our AirBnb and on Friday cooked up a feast of roast chicken, mashed potatoes, gravy, stuffing, green beans and, yes, we found cranberry sauce in South Africa. (After searching a few different stores with no luck, it felt like finding gold.)
We drove off after three days with some very fond memories.